| Document ID (ISN) | 74148 |
| CIS number |
99-1953 |
| ISSN - Serial title |
0170-2327 - Ergo-Med |
| Year |
1999 |
| Convention or series no. |
|
| Author(s) |
Beyersmann D., Hartwig A. |
| Title |
Combined effects of carcinogenic metal compounds |
| Original title |
Kombinationswirkungen bei krebserzeugenden Metallverbindungen [in German] |
| Bibliographic information |
July-Aug.1999, Vol.23, No.4, p.170-175. Illus. 21 ref. |
| Abstract |
Arsenic, beryllium, cadmium, chromates, cobalt and nickel have been added to the list of carcinogenic substances by German and international authorities. Present knowledge of the combined effects of these carcinogens with further carcinogenic substances such as polycyclic aromatic hydrocarbons or nitrosamines is reviewed. No findings concerning these combined effects are available from epidemiologic studies. Animal experiments provide evidence of cobalt chloride enhancing the carcinogenic effect of benzo(a)pyrene. In vitro studies of the influence of carcinogenic metal compounds and other substances on DNA repair shows an enhanced cancer risk in the case of combined exposure to compounds of arsenic, cadmium, cobalt and nickel and mutagens such as ultraviolet radiation, oxidants and alkylating substances. Topics: alkylating substances; aromatic hydrocarbons; arsenic and compounds; beryllium and compounds; cadmium and compounds; carcinogens; chromates; cobalt and compounds; cocarcinogenic effects; DNA; literature survey; metal salts; metals; mutagens; nickel and compounds; nitroso amines; polycyclic hydrocarbons; synergism; ultraviolet radiation. |
| Descriptors (primary) |
carcinogens; synergism; metal salts; metals |
| Descriptors (secondary) |
literature survey; chromates; cadmium and compounds; mutagens; cobalt and compounds; nickel and compounds; cocarcinogenic effects; arsenic and compounds; aromatic hydrocarbons; beryllium and compounds; ultraviolet radiation; DNA; nitroso amines; polycyclic hydrocarbons; alkylating substances |
| Document type |
D - Periodical articles |
| Country / State or Province | Germany |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Inorganic substances
|
