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CISDOC database

Document ID (ISN)74018
CIS number 99-1979
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 1999
Convention or series no.
Author(s) Brüning T., Chronz C., Thier R., Havelka J., Ko Y., Bolt H.M.
Title Occurrence of urinary tract tumours in miners highly exposed to dinitrotoluene
Bibliographic information Mar. 1999, Vol.41, No.3, p.144-149. 33 ref.
Abstract Higher than expected incidences of urothelial and renal cell tumours were found in a group of underground copper miners with high exposures to explosives containing dinitrotoluene. Categorization of the renal cell tumour cases by exposure revealed no dose-dependency concerning explosives and was similar to that of a representative group of formerly dinitrotoluene-exposed workers, whereas the urothelial tumour cases were predominantly confined to the high-exposure categories. These results along with results of genotyping indicate the possibility of human carcinogenicity of dinitrotoluene with regard to urothelium as the target tissue. Topics: bladder tumour; dinitrotoluene; copper mining; dose-response relationship; epidemiologic study; explosives; genito-urinary system diseases; latency; length of exposure; neoplasms; renal cancer; skin absorption.
Descriptors (primary) explosives; copper mining; bladder tumour; dinitrotoluene
Descriptors (secondary) genito-urinary system diseases; latency; skin absorption; neoplasms; epidemiologic study; length of exposure; dose-response relationship; renal cancer
Document type D - Periodical articles
Country / State or ProvinceGermany
Subject(s) Mines and quarries
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the kidney and the urinary system
Aliphatic nitro compounds
Mining and quarrying