| Document ID (ISN) | 73932 |
| CIS number |
99-1937 |
| ISSN - Serial title |
0731-3810 - Journal of Toxicology - Clinical Toxicology |
| Year |
1999 |
| Convention or series no. |
|
| Author(s) |
Barceloux D.G. |
| Title |
Chromium |
| Bibliographic information |
1999, Vol.37, No.2, p.173-194. 165 ref. |
| Abstract |
Hexavalent chromium is a skin and mucous membrane irritant and some hexavalent compounds are strong corrosive agents. Hexavalent chromium compounds also produce an allergic contact dermatitis characterized by eczema. Hexavalent chromium is recognized by the International Agency for Research on Cancer and by the US Toxicology Program as a pulmonary carcinogen. Increased risk of lung cancer occurs primarily in workers exposed to hexavalent chromium dust during the refining of chromite ore and the production of chromate pigments. There is currently insufficient evidence to advocate the use of ascorbic acid in the management of systemic chromium toxicity. Topical ascorbic acid may reduce dermal hexavalent chromium exposure, but this must be confirmed in controlled studies. Topics: acute toxicity; allergens; animal experiments; carcinogenic effects; vitamin C; chromium; caustic substances; chromium and compounds; chronic toxicity; corrosion inhibitors; determination in blood; determination in hair; determination in urine; dose-response relationship; electroplating; first aid; glass industry; health hazards; irritants; literature survey; lung cancer; match manufacturing industry; medical treatment; metabolic process; pigments; sensitization dermatitis; tanning industry; threshold limit values; toxicology; urinary excretion; wood preservatives. |
| Descriptors (primary) |
toxicology; chromium and compounds; health hazards |
| Descriptors (secondary) |
literature survey; determination in hair; threshold limit values; allergens; irritants; match manufacturing industry; sensitization dermatitis; acute toxicity; metabolic process; vitamin C; urinary excretion; pigments; caustic substances; lung cancer; electroplating; first aid; animal experiments; chronic toxicity; dose-response relationship; carcinogenic effects; tanning industry; glass industry; determination in blood; medical treatment; chromium; determination in urine; corrosion inhibitors; wood preservatives |
| Document type |
D - Periodical articles |
| Country / State or Province | USA |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Inorganic substances
|
