ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)73345
CIS number 99-1236
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 1998
Convention or series no.
Author(s) Brouwer D.H., Hoogendoorn L., Bos P.M.J, Boogaard P.J., van Hemmen J.J.
Title Proposal for the assessment of quantitative dermal exposure limits in occupational environments: Part 2. Feasibility study for application in an exposure scenario for MDA by two different dermal exposure sampling methods
Bibliographic information Dec. 1998, Vol.55, No.12, p.805-811. Illus. 51 ref.
Abstract Six workers were monitored for exposure to 4,4'-methylene dianiline (MDA) in a factory that made glass fibre reinforced resin pipes. Dermal exposure of the hands and forearms was assessed during week 1 by a surrogate skin technique (cotton monitoring gloves) and during week 2 by a removal technique (hand wash). Urinary excretion of MDA over 24 hours was also measured during week 2. Surface contamination of the workplace and equipment was monitored qualitatively by colorimetric wipe samples. Significant differences between the mean daily exposure of the hands (for both weeks and sampling methods) were found for all workers. The results of the colorimetric wipe samples indicated a general contamination of the workplace and equipment. Cumulative hand wash and MDA excretion results over a week showed a high correlation. It is concluded that both dermal exposure monitoring methods were applicable and showed a compatible performance in the present exposure scenario, where the exposure relevant to dermal absorption is considered mainly restricted to hands. For Part 1, see CIS 99-1235. Topics: methylenedianiline; colorimetry; description of technique; evaluation of technique; exposure evaluation; exposure tests; limitation of exposure; sampling methods; skin absorption; urinary excretion.
Descriptors (primary) methylenedianiline; exposure evaluation; skin absorption
Descriptors (secondary) urinary excretion; limitation of exposure; evaluation of technique; colorimetry; exposure tests; description of technique; sampling methods
Document type D - Periodical articles
Country / State or ProvinceNetherlands
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Aromatic amines
Exposure evaluation