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CISDOC database

Document ID (ISN)73344
CIS number 99-1235
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 1998
Convention or series no.
Author(s) Bos P.M.J., Brouwer D.H., Stevenson H., Boogaard P.J., de Kort W.L.A.M., van Hemmen J.J.
Title Proposal for the assessment of quantitative dermal exposure limits in occupational environments: Part 1. Development of a concept to derive a quantitative dermal occupational exposure limit
Bibliographic information July-Dec. 1998, Vol.55, No.12, p.795-804. Illus. 48 ref.
Abstract An attempt was made to develop a quantitative dermal occupational exposure limit (DOEL) complementary to respiratory occupational exposure limits (OELs). The DOEL refers to the total dose deposited on the skin during a working shift. Based on available data and experience a theoretical procedure for the assessment of a DOEL was developed. A DOEL was derived for cyclophosphamide and 4,4'-methylene dianiline (MDA) according to this procedure. The DOEL for MDA was tested for applicability in an occupational exposure scenario. The proposed concept for a DOEL is relevant and can be made applicable for health surveillance in occupational situations where dermal exposure contributes notably to systematic exposure. For Part 2, see CIS 99-1236. Topics: methylenedianiline; description of technique; determination of exposure limits; exposure tests; limitation of exposure; skin absorption; threshold limit values.
Descriptors (primary) methylenedianiline; determination of exposure limits; skin absorption
Descriptors (secondary) threshold limit values; description of technique; exposure tests; limitation of exposure
Document type D - Periodical articles
Country / State or ProvinceNetherlands
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Aromatic amines