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CISDOC database

Document ID (ISN)73014
CIS number 99-917
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 1999
Convention or series no.
Author(s) Verplanke A.J.W., Leummens M.H.L., Herber R.F.M.
Title Occupational exposure to tetrachloroethene and its effects on the kidneys
Bibliographic information Jan. 1999, Vol.41, No.1, p.11-16. 24 ref.
Abstract The effects of tetrachloroethylene (TCE) exposure on the kidneys were investigated in 82 exposed and 19 nonexposed workers from four dry-cleaning shops. The mean inhaled amount of TCE in the exposed group was 8.4mg/m3, corresponding to a mean 8-hour time-weighted average exposure of 7.9mg/m3. A chronic dose index (CDI) was estimated from data on the current TCE dose and the occupational history of individual subjects. The mean CDI in the exposed group was 400 months x mg/m3. Effects on the tubules were assessed with the parameters N-acetyl-β-D-glucosaminidase, β-galactosidase, alanine aminopeptidase, and retinol-binding protein (RBP) in urine. Early effects on the glomeruli were monitored with the parameter albumin in urine. Total protein in urine was determined for the general assessment of effects on the glomeruli and tubules. The tubular parameter RBP was increased in the exposed group compared with the nonexposed group. In conclusion, occupational exposure to TCE may cause a minor effect on the tubular RBP at exposure levels below the Dutch occupational exposure limit (240mg/m3). Topics: tetrachloroethylene; beta-galactosidase; aminopeptidase; determination in urine; dry cleaning; enzymological tests; epidemiologic study; exposure evaluation; limitation of exposure; renal dysfunction; urinary metabolites.
Descriptors (primary) renal dysfunction; dry cleaning; tetrachloroethylene
Descriptors (secondary) aminopeptidase; beta-galactosidase; limitation of exposure; enzymological tests; epidemiologic study; urinary metabolites; determination in urine; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceNetherlands
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the kidney and the urinary system
Halogenated hydrocarbons
Laundries and dry cleaning