| Document ID (ISN) | 72943 |
| CIS number |
99-922 |
| ISSN - Serial title |
1351-0711 - Occupational and Environmental Medicine |
| Year |
1998 |
| Convention or series no. |
|
| Author(s) |
Nadif R., Bourgkard E., Dusch M., Bernadac P., Bertrand J.P., Mur J.M., Pham Q.T. |
| Title |
Relations between occupational exposure to coal mine dusts, erythrocyte catalase and Cu++/Zn++ superoxide dismutase activities, and the severity of coal workers' pneumoconiosis |
| Bibliographic information |
Aug. 1998, Vol.55, No.8, p.533-540. 39 ref. |
| Abstract |
Blood samples were obtained from miners without coal workers' pneumoconiosis (CWP) exposed to low dust concentrations for 4 or more years, or exposed to high dust concentrations for 14 or more years, and from retired miners with CWP. Estimated cumulative exposure to dust was strongly positively related to erythrocyte catalase activity and strongly negatively related to Cu++/Zn++ superoxide dismutase activity only in miners exposed to high dust concentrations for ≥14 years. Moreover, catalase activity was strongly related to the severity of CWP as determined by chest radiography. Results are in good agreement with the hypothesis that production of reactive oxygen species may be an important event in the exposure to coal mine dusts and the severity of CWP. Topics: coal mining; coalworkers pneumoconiosis; determination in blood; enzyme activity determination; enzyme activity; epidemiologic study; erythrocytes; respirable dust; superoxide dismutase. |
| Descriptors (primary) |
enzyme activity; coalworkers pneumoconiosis; coal mining; respirable dust |
| Descriptors (secondary) |
superoxide dismutase; epidemiologic study; erythrocytes; enzyme activity determination; determination in blood |
| Document type |
D - Periodical articles |
| Country / State or Province | France |
| Subject(s) |
Mines and quarries
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Mining and quarrying
Pneumoconioses
Blood diseases
|
