| Document ID (ISN) | 72625 |
| CIS number |
99-532 |
| ISSN - Serial title |
1232-1087 - International Journal of Occupational Medicine and Environmental Health |
| Year |
1998 |
| Convention or series no. |
|
| Author(s) |
Kaneko T., Wang P.Y., Sato A. |
| Title |
Development of occupational exposure limits in Japan |
| Bibliographic information |
1998, Vol.11, No.1, p.81-98. 86 ref. |
| Abstract |
The development of occupational exposure limits (OELs) in Japan is described using benzene and trichloroethylene as examples. To establish the OEL for benzene, the OEL committee of the Japan Society for Occupational Health (JSOH) calculated the risk of benzene-induced leukaemia by means of an average relative risk model. It was decided that benzene exposure should be controlled by a reference value corresponding to a lifetime risk (10-3 or 10-4) of leukaemia rather than by a time-weighted average (TWA) concentration. These lifetime risks correspond to an OEL for benzene of 1ppm and 0.1ppm respectively. Concerning trichloroethylene, the OEL committee felt it was not appropriate to assume carcinogenicity, and that the OEL should be established on other, especially neurological, criteria. Based on findings that long-term exposure to trichloroethylene at 50ppm can cause neurotoxic effects, the committee proposed an occupational reference value of 25ppm. General environmental standards should be about 1/1,000 of occupational values. Topics: animal experiments; benzene; carcinogenic effects; trichloroethylene; epidemiological aspects; harmful substances; hazard evaluation; hepatotoxic effects; Japan; leukaemia; limitation of exposure; mutagenic effects; nephrotoxic effects; neurotoxic effects; threshold limit values; toxicity evaluation. |
| Descriptors (primary) |
Japan; trichloroethylene; limitation of exposure; harmful substances; benzene |
| Descriptors (secondary) |
mutagenic effects; neurotoxic effects; threshold limit values; leukaemia; hepatotoxic effects; nephrotoxic effects; hazard evaluation; toxicity evaluation; animal experiments; carcinogenic effects; epidemiological aspects |
| Document type |
D - Periodical articles |
| Country / State or Province | Japan |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Halogenated hydrocarbons
Genetic factors in reaction to exposures
Aromatic hydrocarbons
|
