| Document ID (ISN) | 69830 |
| CIS number |
97-1589 |
| ISSN - Serial title |
0091-6765 - Environmental Health Perspectives |
| Year |
1996 |
| Convention or series no. |
|
| Author(s) |
Osterman-Golkar S., Bond J.A. |
| Title |
Biomonitoring of 1,3-butadiene and related compounds |
| Bibliographic information |
Oct. 1996, Vol.104, Suppl.5, p.907-915. Illus. 85 ref. |
| Abstract |
Studies on the biomonitoring of butadiene and related compounds are reviewed. Sources of exposure to butadiene (carcinogenic in mice and rats) include cigarette smoke and emissions from butadiene production, storage, transport and use; the most likely route of uptake in inhalation. Biomonitoring is based on chemical analysis of butadiene in exhaled breath, levels of butadiene metabolites (epoxides) in blood and urine, or adducts of metabolites with DNA or blood proteins. Biomonitoring methods need to be developed for diepoxybutane and other reactive butadiene metabolites. |
| Descriptors (primary) |
carcinogens; exposure tests; biological effects; butadiene |
| Descriptors (secondary) |
literature survey; metabolic process; DNA; determination in urine; determination in blood; determination in exhaled air; toxic metabolites |
| Document type |
D - Periodical articles |
| Country / State or Province | Sweden; USA |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Butadiene
Biological monitoring
Aliphatic and alicyclic hydrocarbons
|
