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CISDOC database

Document ID (ISN)69814
CIS number 97-1607
ISSN - Serial title 0025-7818 - Medicina del lavoro
Year 1996
Convention or series no.
Author(s) Valentino M.
Title Residual electroneurographic modifications in subjects with n-hexane induced polyneuropathy: A follow-up study
Bibliographic information July-Aug. 1996, Vol.87, No.4, p.289-296. 22 ref.
Abstract This study reports on the neurological examinations of 90 shoe workers diagnosed with polyneuropathy. The examinations were repeated at least one year after cessation of occupational exposure to n-hexane (the subjects were divided into two groups: 63 had the re-examination less than 10 years after cessation of exposure, while 27 had it after more than 10 years). The aetiologic agent of polyneuropathy was thought to be 2,5-hexanedione, a neurotoxic metabolite of n-hexane. The follow-up study demonstrated a complete recovery of motor conduction velocity in both groups of subjects. On the other hand, even though there was improvement in other neurological functions (conduction velocity and distal latency of the sensory nerves and distal latency of the ulnar nerve) among the subjects in both groups, there was a statistically significant deterioration in these functions independent of the time that had elapsed since cessation of exposure.
Descriptors (primary) 2,5-hexanedione; hexane; shoemakers; electroneuromyography; neurological effects; polyneuritis
Descriptors (secondary) long-term study; Italy
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Footwear, leather and fur industry
Diseases of the nervous system
Aliphatic and alicyclic hydrocarbons