| Document ID (ISN) | 69754 |
| CIS number |
97-1581 |
| ISSN - Serial title |
1077-3525 - International Journal of Occupational and Environmental Health |
| Year |
1995 |
| Convention or series no. |
|
| Author(s) |
Inoue O., et al. |
| Title |
A sensitive HPLC method for determination of mandelic acid in urine, and its application to biological monitoring of ethylbenzene-exposed Chinese workers |
| Bibliographic information |
July/Sep. 1995, Vol.1, No.3, p.245-251. Illus. 35 ref. |
| Abstract |
A high-pressure liquid chromatography (HPLC) method was developed for determination of mandelic acid in urine as a marker of exposure to ethylbenzene at low concentrations. Application of the technique to urine samples from 360 ethylbenzene-exposed workers and 281 unexposed controls showed that the method is highly sensitive and results are reproducible. The detection limit of 0.07mg/L urine is sensitive enough for monitoring of exposures well below one tenth of the occupational exposure limit of 100ppm. Further analysis showed that smoking reduces the excretion of mandelic acid in urine. |
| Descriptors (primary) |
exposure tests; ethylbenzene |
| Descriptors (secondary) |
mandelic acid; smoking; high-pressure liquid chromatography; determination in urine; urinary metabolites |
| Document type |
D - Periodical articles |
| Country / State or Province | Japan |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Biological monitoring
Aromatic hydrocarbons
|
