| Document ID (ISN) | 69029 |
| CIS number |
97-871 |
| ISSN - Serial title |
0040-6376 - Thorax |
| Year |
1997 |
| Convention or series no. |
|
| Author(s) |
Hnizdo E., Murray J., Klempman S. |
| Title |
Lung cancer in relation to exposure to silica dust, silicosis and uranium production in South African gold miners |
| Bibliographic information |
Mar. 1997, Vol.52, p.271-275. 19 ref. |
| Abstract |
In a cohort of 2260 South African gold miners, 78 cases of lung cancer were found during the follow-up period from 1970 to 1986. The risk of lung cancer was associated with tobacco smoking, cumulative dust exposure, duration of underground mining and silicosis. No association was found with uranium production. The results cannot be interpreted definitively in terms of causal association. High levels of exposure to silica dust on its own are important in the pathogenesis of lung cancer and silicosis is either coincidental or represents an increased risk. The risk is also increased in miners spending many hours underground, in which case high levels of silica dust exposure may be a surrogate for exposure to radon daughters. |
| Descriptors (primary) |
mineral dust; South Africa; radon daughters; silica; uranium mining; lung cancer; silicosis; risk factors; gold mining; smoking |
| Descriptors (secondary) |
cohort study |
| Document type |
D - Periodical articles |
| Country / State or Province | South Africa |
| Subject(s) |
Dust, aerosols and related diseases
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Inorganic substances
Mining and quarrying
Radon
Pneumoconioses
Smoking
Diseases of the respiratory system (except for pneumoconiosis & similar)
|
