| Document ID (ISN) | 68536 |
| CIS number |
97-197 |
| ISSN - Serial title |
1351-0711 - Occupational and Environmental Medicine |
| Year |
1995 |
| Convention or series no. |
|
| Author(s) |
Schins R.P.F., Borm P.J.A. |
| Title |
Epidemiological evaluation of release of monocyte TNF-alpha as an exposure and effect marker in pneumoconiosis: A five year follow up study of coal workers |
| Bibliographic information |
July 1995, Vol.52, No.7, p.441-450. 31 ref. |
| Abstract |
Study to determine the reproducibility with previous cross-sectional findings and the predictive value of initial release of tumour necrosis factor-alpha (TNF-alpha) towards later progression of coalworkers' pneumoconiosis (CWP). Release of monocyte TNF-alpha after in vitro stimulation with coal mine dust, silica and endotoxin was measured in 104 retired miners and was related to stage of CWP and cumulative exposure. A subgroup of 46 miners was screened by high resolution computed tomography (HRCT). As observed previously, dust stimulated release of TNF-alpha was increased in miners, especially in the early stages of pneumoconiosis. Cumulative exposure was related to pneumoconiotic stage but not to release of TNF-alpha. Initial concentrations of TNF-alpha were related to later progression of CWP. The results show the significant involvement of TNF-alpha in pneumoconiosis in humans induced by coal dust and that this routine test possibly constitutes a powerful tool to estimate individual prognosis of pneumoconiotic disease, even after the end of occupational exposure. |
| Descriptors (primary) |
coal dust; hazard criteria; coalworkers pneumoconiosis; coal mining; prognosis |
| Descriptors (secondary) |
evolution of disease; silica; long-term study; comparative study; biological and medical tests; tomography; in vitro experiments |
| Document type |
D - Periodical articles |
| Country / State or Province | Netherlands |
| Subject(s) |
Mines and quarries
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Pneumoconioses
Mining and quarrying
|
