| Document ID (ISN) | 68311 |
| CIS number |
97-104 |
| ISSN - Serial title |
1351-0711 - Occupational and Environmental Medicine |
| Year |
1995 |
| Convention or series no. |
|
| Author(s) |
Partanen R., Koskinen H., Hemminki K. |
| Title |
Tumour necrosis factor-alpha (TNF-alpha) in patients who have asbestosis and develop cancer |
| Bibliographic information |
1995, Vol.52, p.316-319. Illus. 15 ref. |
| Abstract |
Concentrations of tumour necrosis factor-alpha (TNF-alpha) were assayed by radioimmunoassay in serum samples collected between 1981 and 1987 from 111 patients with asbestosis who where at a high risk of cancer. Follow up of these patients until 1993 showed that 38 had developed cancer (27 lung, three mesothelioma and eight diverse malignancies). The mean serum concentrations of TNF-alpha given in fmol/100µL serum in all the cases with cancer and the cases with lung cancer were significantly higher than the mean concentrations in the exposed controls. The serum concentrations of TNF-alpha correlated moderately with cancer, lung cancer and Neu oncoproteins and epidermal growth factor receptor. Also, there was a significant correlation between development of cancer and severity or progression of asbestosis. There was no correlation between the concentrations of TNF-alpha and severity or progression of asbestosis. The results showed high concentrations of TNF-alpha in the patients who had cancer. TNF-alpha may offer an auxiliary method in early diagnosis of cancers related to asbestosis. |
| Descriptors (primary) |
early diagnosis; lung cancer; immunogenic factors; cancer; asbestosis |
| Descriptors (secondary) |
special radiological techniques; asbestos; comparative study; immunology; serological reactions; long-term study |
| Document type |
D - Periodical articles |
| Country / State or Province | Finland |
| Subject(s) |
Dust, aerosols and related diseases
|
| Broad subject area(s) |
Occupational medicine, epidemiology
|
| Browse category(ies) |
Pneumoconioses
Diseases of the respiratory system (except for pneumoconiosis & similar)
|
