| Document ID (ISN) | 68104 |
| CIS number |
96-2207 |
| ISSN - Serial title |
1351-0711 - Occupational and Environmental Medicine |
| Year |
1994 |
| Convention or series no. |
|
| Author(s) |
Tardiff R., Sato A., Laparé S., Brodeur J. |
| Title |
Ethanol induced modification of m-xylene toxicokinetics in humans |
| Bibliographic information |
Mar. 1994, Vol.51, No.3, p.187-191. Illus. 26 ref. |
| Abstract |
This study was undertaken to determine whether previous subacute treatment with ethanol could modify the kinetics of m-xylene in humans. A group of six volunteers was exposed twice to either 100 or 400ppm of m-xylene during two hours. Ethanol was given orally in the early evening on each of two consecutive days before exposures (total ethanol intake of 137g). Overall, this study showed that the effect of enzyme induction on the metabolism of m-xylene, after ethanol ingestion, depends on the exposure concentration and is not likely to occur as long as the exposure concentrations remain under the current maximum allowable concentration (100ppm) in the workplace. |
| Descriptors (primary) |
metabolic process; ethanol; medical treatment; m-xylene; inhibition of metabolism |
| Descriptors (secondary) |
human experiments; medical examinations; biological and medical tests; urine monitoring; blood monitoring |
| Document type |
D - Periodical articles |
| Country / State or Province | Canada; Japan |
| Subject(s) |
Medicine, hygiene and first aid
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Aromatic hydrocarbons
Alcohols
|
