Document ID (ISN) | 66290 |
CIS number |
96-762 |
ISSN - Serial title |
0271-3586 - American Journal of Industrial Medicine |
Year |
1995 |
Convention or series no. |
|
Author(s) |
Fučić A., Hitrec V., Garaj-Vrhovac V., Barkovic D., Kubelka D. |
Title |
Relationship between locations of chromosome breaks induced by vinyl chloride monomer and lymphocytosis |
Bibliographic information |
1995, Vol.27, No.4, p.565-571. 33 ref. |
Abstract |
The distribution of vinyl chloride monomer (VCM)-induced chromosome breaks was studied in cultured lymphocytes of 20 workers in a polyvinyl chloride plant. VCM concentration was 1ppm, periodically reaching 300ppm for a short period. The examined workers had considerably higher values of chromosome aberrations and sister-chromatid exchanges than did a non-exposed control group. Exposure to VCM caused lymphocytosis together with disturbances of mitogenic activity in lymphocytes stimulated by phytohaemagglutinin. Results of G-banding showed that sites of chromosome breakpoints caused by VCM can be related to lymphatic tissue disorders. Lymphomas and leukaemias can be expected even with a VCM concentration of 1ppm. |
Descriptors (primary) |
vinyl chloride; plastics industry; chromosome changes; haemic and lymphatic diseases |
Descriptors (secondary) |
analysis of chromosome aberrations; agranulocytosis |
Document type |
D - Periodical articles |
Country / State or Province | Croatia |
Subject(s) |
Toxic and dangerous substances
|
Broad subject area(s) |
Chemical safety
|
Browse category(ies) |
Blood diseases Antifertility and prenatal effects Halogenated hydrocarbons Chemical industry Plastics industry Genetic factors in reaction to exposures
|