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Document ID (ISN)66290
CIS number 96-762
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 1995
Convention or series no.
Author(s) Fučić A., Hitrec V., Garaj-Vrhovac V., Barkovic D., Kubelka D.
Title Relationship between locations of chromosome breaks induced by vinyl chloride monomer and lymphocytosis
Bibliographic information 1995, Vol.27, No.4, p.565-571. 33 ref.
Abstract The distribution of vinyl chloride monomer (VCM)-induced chromosome breaks was studied in cultured lymphocytes of 20 workers in a polyvinyl chloride plant. VCM concentration was 1ppm, periodically reaching 300ppm for a short period. The examined workers had considerably higher values of chromosome aberrations and sister-chromatid exchanges than did a non-exposed control group. Exposure to VCM caused lymphocytosis together with disturbances of mitogenic activity in lymphocytes stimulated by phytohaemagglutinin. Results of G-banding showed that sites of chromosome breakpoints caused by VCM can be related to lymphatic tissue disorders. Lymphomas and leukaemias can be expected even with a VCM concentration of 1ppm.
Descriptors (primary) vinyl chloride; plastics industry; chromosome changes; haemic and lymphatic diseases
Descriptors (secondary) analysis of chromosome aberrations; agranulocytosis
Document type D - Periodical articles
Country / State or ProvinceCroatia
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Blood diseases
Antifertility and prenatal effects
Halogenated hydrocarbons
Chemical industry
Plastics industry
Genetic factors in reaction to exposures