|Document ID (ISN)||65743|
|ISSN - Serial title
||1040-8444 - Critical Reviews in Toxicology
|Convention or series no.
||Smith R.P., Wilcox D.E.
||Toxicology of selected nitric oxide-donating xenobiotics, with particular reference to azide
||Oct. 1994, Vol.24, No.4, p.355-377. 129 ref.
||Although nitric oxide (NO) is responsible for a variety of normal physiological functions, it has also been implicated in several pathophysiological processes. Recently, a variety of xenobiotics have been shown to owe their biological activity in vivo to their biotransformation to NO. As reviewed here, NO does not appear to contribute importantly to the toxicity of NO donors nitrite, hydroxylamine or nitroprusside. However, it is not clear if NO generated in vivo from sodium azide contributes in a major way to its toxicity. Some evidence suggests a tendency for azide to produce low-grade cumulative toxicity. Azide is widely used as a preservative in aqueous laboratory reagents and as a propellant in automobile air bags and aircraft escape chutes. To protect workers who handle these devices and others who may come into contact with the sodium azide propellant in these systems, the rudimentary knowledge of azide toxicity needs to be expanded.
||toxic effects; azides; nitric oxide; antibiotics; nitrogen oxides; drugs
||literature survey; sodium azide; hydroxylamine; vasodilatation
||D - Periodical articles
|Country / State or Province||USA|
||Toxic and dangerous substances
|Broad subject area(s)