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CISDOC database

Document ID (ISN)65367
CIS number 95-1811
ISBN(s) 87-7534-388-6
Year 1992
Convention or series no.
Author(s) Johnsen H., Lund S.P., Matikainen E., Midtgård U., Simonsen L., Wennberg A.
Nordic Council of Ministers
Title Occupational neurotoxicity: Criteria document for evaluation of existing data
Bibliographic information National Institute of Occupational Health, Lersø Parkallé 105, 2100 København Ø, Denmark, 2nd. ed., Oct. 1992. 52p. Illus. 60 ref.
Abstract Report of a working group on criteria for the evaluation and classification of neurotoxic chemicals. A chemical is considered to be neurotoxic if it is capable of inducing a consistent pattern of neural dysfunction or lesion in the nervous system. Criteria were developed for deciding if published evidence for a specific chemical fit this definition. The approach follows that used by the International Agency for Research on Cancer for evaluating data on carcinogenicity. The criteria were tested by evaluating selected research papers on manganese, aluminium, tetrahydrofuran, cyclohexanone, dichlorvos, trichloroethylene, formaldehyde, triorthocresyl phosphate, n-hexane and vinyl chloride. Formaldehyde was not classifiable. Cyclohexanone, dichlorvos, tetrahydrofuran and vinyl chloride were classified as possibly neurotoxic and the others as definitely neurotoxic.
Descriptors (primary) neurotoxic effects; tetrahydrofuran; formaldehyde; manganese; Nordic Countries; vinyl chloride; evaluation of results; cyclohexanone; hexane; dichlorvos; triorthocresyl phosphate; aluminium; trichloroethylene
Descriptors (secondary) criteria document; literature survey
Document type E - Books, reports, proceedings
Country / State or ProvinceDenmark
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Inorganic substances
Aldehydes
Esters and salts
Diseases of the nervous system
Aliphatic and alicyclic hydrocarbons
Halogenated hydrocarbons
Ketones
Heterocyclic compounds