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Document ID (ISN)63996
CIS number 95-581
ISSN - Serial title 1250-3274 - Archives des maladies professionnelles et de médecine du travail
Year 1994
Convention or series no.
Author(s) Ameille J., Villoingt L.
Title Prognostic value of bronchial hyperresponsiveness in car painters exposed to isocyanates
Original title Valeur pronostique de l'hyperréactivité bronchique chez des peintres automobiles exposés aux isocyanates [in French]
Bibliographic information 1994, Vol.55, No.5, p.317-321. 34 ref.
Abstract Thirty five painters exposed to HDI and HDI prepolymers underwent two respiratory examinations consisting of a standardized questionnaire and measurement of pulmonary function including a methacholine challenge over a 2-year period. Non specific bronchial hyperresponsiveness (NSBH) was present initially in 11 workers and was associated with a higher tobacco consumption, a higher prevalence of respiratory symptoms and lower baseline values of lung function tests. Compared with car painters without NSBH, those with NSBH had a greater, though not significant, reduction in FEV (76mL/year versus 37mL/year). No case of asthma was diagnosed neither in car painters with NSBH, nor in those without. So, despite the weak number of patients in our study, it appears that the presence of NSBH in car painters exposed to isocyanates is not a good predictor of asthma. On the other hand, performing a test of bronchial hyperreactivity might be used as means of identifying subjects at risk for chronic obstructive pulmonary disease.
Descriptors (primary) isocyanates; hexamethylene diisocyanate; prognosis; allergic reactivity; motor vehicle industry; hypersensitivity; prediction; paint spraying
Descriptors (secondary) respiratory impairment; early diagnosis
Document type D - Periodical articles
Country / State or ProvinceFrance
Subject(s) Other industries and occupations
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Allergies
Surface treatment
Cyano compounds
Motor vehicle manufacturing industry