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Document ID (ISN)63576
CIS number 95-228
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 1994
Convention or series no.
Author(s) Türkel B., Egeli U.
Title Analysis of chromosomal aberrations in shoe workers exposed long term to benzene
Bibliographic information Jan. 1994, Vol.51, No.1, p.50-53. 19 ref.
Abstract Cytogenetic analysis of peripheral blood lymphocytes was used to compare 58 shoe workers (57 men and one woman) exposed to benzene and 20 subjects selected from the general population not exposed to particular mutagenic or carcinogenic agents (control group). Frequencies of damaged cells, including gaps, breaks, and rearrangements (acentric fragments, deletions, translocations) were scored for both groups. The incidence of chromosomal aberrations (particularly chromatid gaps and breaks) in the exposed group was significantly higher than in the control group. There were no effects of smoking and only breaks were affected by alcohol. Nor was there a significant relation between the working period in the group exposed to benzene and frequency of chromosomal aberrations. Recommended safety measure: lowering of the limit value from 20ppm to 1ppm and improvement of working conditions.
Descriptors (primary) benzene; shoe industry; chromosome changes; long-term exposure
Descriptors (secondary) threshold limit values; lymphocytes; frequency rates; blood cytology; analysis of chromosome aberrations; case-control study
Document type D - Periodical articles
Country / State or ProvinceTurkey
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Footwear, leather and fur industry
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Aromatic hydrocarbons