Document ID (ISN) | 63271 |
CIS number |
94-1972 |
ISSN - Serial title |
0096-1736 - Journal of Occupational Medicine |
Year |
1994 |
Convention or series no. |
|
Author(s) |
Sessink P.J.M., Timmersmans J.L., Anzion R.B.M., Bos R.P. |
Title |
Assessment of occupational exposure of pharmaceutical plant workers to 5-fluorouracil - Determination of α-fluoro-β-alanine in urine |
Bibliographic information |
Jan. 1994, Vol.36, No.1, p.79-83. Illus. 17 ref. |
Abstract |
The exposure of pharmaceutical plant workers involved in drug compounding and drug production to 5-fluorouracil (5FU) was studied. 5FU was determined by analysis of air and wipe samples. It was detected in the air (75µg/m3), on the floor (particularly after routine cleaning, up to 630ng/cm2), on persons and on gloves. The uptake of 5FU was established by determination of α-fluoro-β-alanine, the main metabolite of 5FU, in the urine of the workers. Evidence for exposure to 5FU was therefore found. |
Descriptors (primary) |
antineoplastic drugs; pharmaceutical industry; exposure evaluation; 5-fluorouracil |
Descriptors (secondary) |
determination in urine; urinary metabolites |
Document type |
D - Periodical articles |
Country / State or Province | Netherlands |
Subject(s) |
Toxic and dangerous substances
|
Broad subject area(s) |
Chemical safety
|
Browse category(ies) |
Pharmaceutical industry Exposure evaluation
|