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Document ID (ISN)63271
CIS number 94-1972
ISSN - Serial title 0096-1736 - Journal of Occupational Medicine
Year 1994
Convention or series no.
Author(s) Sessink P.J.M., Timmersmans J.L., Anzion R.B.M., Bos R.P.
Title Assessment of occupational exposure of pharmaceutical plant workers to 5-fluorouracil - Determination of α-fluoro-β-alanine in urine
Bibliographic information Jan. 1994, Vol.36, No.1, p.79-83. Illus. 17 ref.
Abstract The exposure of pharmaceutical plant workers involved in drug compounding and drug production to 5-fluorouracil (5FU) was studied. 5FU was determined by analysis of air and wipe samples. It was detected in the air (75µg/m3), on the floor (particularly after routine cleaning, up to 630ng/cm2), on persons and on gloves. The uptake of 5FU was established by determination of α-fluoro-β-alanine, the main metabolite of 5FU, in the urine of the workers. Evidence for exposure to 5FU was therefore found.
Descriptors (primary) antineoplastic drugs; pharmaceutical industry; exposure evaluation; 5-fluorouracil
Descriptors (secondary) determination in urine; urinary metabolites
Document type D - Periodical articles
Country / State or ProvinceNetherlands
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Pharmaceutical industry
Exposure evaluation