| Document ID (ISN) | 61613 |
| CIS number |
94-314 |
| ISSN - Serial title |
0090-4341 - Archives of Environmental Contamination and Toxicology |
| Year |
1992 |
| Convention or series no. |
|
| Author(s) |
Mueller P.W., Paschal D.C., Hammel R.R., Klincewicz S.L., MacNeil M.L., Spierto B., Steinberg K.K. |
| Title |
Chronic renal effects in three studies of men and women occupationally exposed to cadmium |
| Bibliographic information |
July 1992, Vol.23, No.1, p.125-136. Illus. 44 ref. |
| Abstract |
Sensitive indicators of renal damage were measured in three different populations occupationally exposed to cadmium. The degree of variation in damage and the relative sensitivity of different types of indicators were also examined. The three studies included: (1) men exposed in a cadmium recovery plant; (2) men exposed in a nickel/cadmium battery plant; and (3) women exposed in the latter plant. Renal damage was indicated by three categories of urinary protein. These tests indicate that exposed groups with higher urine cadmium levels had varying degrees of renal damage. All exposed groups showed evidence of renal damage when compared with control groups. Highly significant dose-response relationships for all of the urinary protein tests, including fractional clearances, were found. All of the tests were more sensitive in detecting evidence of subclinical renal damage than serum creatinine, a commonly used indicator of renal function. |
| Descriptors (primary) |
proteins; urinary excretion; renal diseases; determination in urine; urine monitoring; cadmium; renal damage |
| Descriptors (secondary) |
cohort study; dose-response relationship; long-term exposure |
| Document type |
D - Periodical articles |
| Country / State or Province | USA |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Inorganic substances
Biological monitoring
Diseases of the kidney and the urinary system
Cadmium and compounds
|
