Document ID (ISN) | 61587 |
CIS number |
94-320 |
ISSN - Serial title |
0340-5761 - Archives of Toxicology |
Year |
1992 |
Convention or series no. |
|
Author(s) |
Liesivuori J., Laitinen J., Savolainen H. |
Title |
Kinetics and renal effects of formic acid in occupationally exposed farmers |
Bibliographic information |
1992, Vol.66, No.7, p.522-524. Illus. 17 ref. |
Abstract |
Twelve male farmers (38 ± 14 years of age, mean ± SD) were exposed to 7.3 ± 2.2mg formic acid/m3 for 8h in silage making (mean ± SD, N=12). Each gave urine samples immediately, 15h and 30h after the end of the exposure. The excretion of formate was linearly related to the exposure 15 and 30h after exposure. Exposure increased renal ammoniagenesis and urinary calcium at 30h post-exposure. Both biochemical effects may be explained by the interaction of formic acid with the oxidative metabolism of renal tubular cells, as formic acid is a known inhibitor of the cytochrome oxidase. In view of these renal effects, the current hygiene limits may not entirely protect exposed individuals. |
Descriptors (primary) |
formic acid; urinary excretion; calcium; biochemical effects; renal diseases |
Descriptors (secondary) |
forage processing; agriculture; cross-sectional study; permissible levels |
Document type |
D - Periodical articles |
Country / State or Province | Switzerland; Finland |
Subject(s) |
Agriculture, fishing, animal husbandry
|
Broad subject area(s) |
Chemical safety
|
Browse category(ies) |
Inorganic substances Diseases of the kidney and the urinary system
|