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Document ID (ISN)61587
CIS number 94-320
ISSN - Serial title 0340-5761 - Archives of Toxicology
Year 1992
Convention or series no.
Author(s) Liesivuori J., Laitinen J., Savolainen H.
Title Kinetics and renal effects of formic acid in occupationally exposed farmers
Bibliographic information 1992, Vol.66, No.7, p.522-524. Illus. 17 ref.
Abstract Twelve male farmers (38 ± 14 years of age, mean ± SD) were exposed to 7.3 ± 2.2mg formic acid/m3 for 8h in silage making (mean ± SD, N=12). Each gave urine samples immediately, 15h and 30h after the end of the exposure. The excretion of formate was linearly related to the exposure 15 and 30h after exposure. Exposure increased renal ammoniagenesis and urinary calcium at 30h post-exposure. Both biochemical effects may be explained by the interaction of formic acid with the oxidative metabolism of renal tubular cells, as formic acid is a known inhibitor of the cytochrome oxidase. In view of these renal effects, the current hygiene limits may not entirely protect exposed individuals.
Descriptors (primary) formic acid; urinary excretion; calcium; biochemical effects; renal diseases
Descriptors (secondary) forage processing; agriculture; cross-sectional study; permissible levels
Document type D - Periodical articles
Country / State or ProvinceSwitzerland; Finland
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s) Chemical safety
Browse category(ies) Inorganic substances
Diseases of the kidney and the urinary system