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CISDOC database

Document ID (ISN)61087
CIS number 93-1862
ISSN - Serial title 0105-1873 - Contact Dermatitis
Year 1993
Convention or series no.
Author(s) Frosch P.J., Schulze-Dirks A., Hoffmann M., Axthelm I.
Title Efficacy of skin barrier creams - II. Ineffectiveness of a popular "skin protector" against various irritants in the repetitive irritation test in the guinea pig
Bibliographic information Aug. 1993, Vol.29, No.2, p.74-77. 9 ref.
Abstract A popular "skin protector" consisting of an emulsion-like foam of lipophilic and hydrophilic substances (Marly skin) was evaluated in a repetitive irritation test involving the guinea pig described in CIS 93-1861. The product failed to inhibit the irritation due to sodium lauryl sulfate and toluene, and the irritant response of sodium hydroxide was aggravated, as demonstrated by significant differences for all test parameters (clinical score for erythema and scaling, transepidermal water loss, blood flow volume). The results show that protection against chemical irritants may be quite specific and that some formulations may actually be harmful.
Descriptors (primary) irritants; barrier creams; skin protection
Descriptors (secondary) sodium hydroxide; toluene; comparative study; animal experiments; sodium dodecylsulfate
Document type D - Periodical articles
Country / State or ProvinceGermany
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Skin protection