|Document ID (ISN)||61087|
|ISSN - Serial title
||0105-1873 - Contact Dermatitis
|Convention or series no.
||Frosch P.J., Schulze-Dirks A., Hoffmann M., Axthelm I.
||Efficacy of skin barrier creams - II. Ineffectiveness of a popular "skin protector" against various irritants in the repetitive irritation test in the guinea pig
||Aug. 1993, Vol.29, No.2, p.74-77. 9 ref.
||A popular "skin protector" consisting of an emulsion-like foam of lipophilic and hydrophilic substances (Marly skin) was evaluated in a repetitive irritation test involving the guinea pig described in CIS 93-1861. The product failed to inhibit the irritation due to sodium lauryl sulfate and toluene, and the irritant response of sodium hydroxide was aggravated, as demonstrated by significant differences for all test parameters (clinical score for erythema and scaling, transepidermal water loss, blood flow volume). The results show that protection against chemical irritants may be quite specific and that some formulations may actually be harmful.
||irritants; barrier creams; skin protection
||sodium hydroxide; toluene; comparative study; animal experiments; sodium dodecylsulfate
||D - Periodical articles
|Country / State or Province||Germany|
|Broad subject area(s)
||Occupational medicine, epidemiology