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CISDOC database

Document ID (ISN)60743
CIS number 93-1608
ISSN - Serial title 1040-8444 - Critical Reviews in Toxicology
Year 1992
Convention or series no.
Author(s) Johnson E.S.
Title Human exposure to 2,3,7,8-TCDD and risk of cancer
Bibliographic information 1992, Vol.21, No.6, p.451-463. 121 ref.
Abstract Most of the evidence for the carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in humans has centred around whether or not it causes malignant lymphomas (ML) and soft-tissue sarcomas (STS). A critical review of the literature indicates that the evidence does not support a causal role for TCDD in the aetiology of ML. For STS, the evidence does not specifically incriminate TCDD either, although there is room for doubt. Cancer of other sites, particularly of the respiratory system and thyroid, which were found to be statistically significantly in excess in both of the two largest studies of combined cohorts of occupationally exposed workers, were identified as candidate tumours for which a possible aetiological role of TCDD might need investigation in future studies.
Descriptors (primary) tetrachlorodibenzodioxin; lymphoma; neoplasms; aetiology; carcinogenic effects; sarcomas
Descriptors (secondary) literature survey; epidemiologic study; mortality
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Blood diseases
Heterocyclic compounds