|Document ID (ISN)||60743|
|ISSN - Serial title
||1040-8444 - Critical Reviews in Toxicology
|Convention or series no.
||Human exposure to 2,3,7,8-TCDD and risk of cancer
||1992, Vol.21, No.6, p.451-463. 121 ref.
||Most of the evidence for the carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in humans has centred around whether or not it causes malignant lymphomas (ML) and soft-tissue sarcomas (STS). A critical review of the literature indicates that the evidence does not support a causal role for TCDD in the aetiology of ML. For STS, the evidence does not specifically incriminate TCDD either, although there is room for doubt. Cancer of other sites, particularly of the respiratory system and thyroid, which were found to be statistically significantly in excess in both of the two largest studies of combined cohorts of occupationally exposed workers, were identified as candidate tumours for which a possible aetiological role of TCDD might need investigation in future studies.
||tetrachlorodibenzodioxin; lymphoma; neoplasms; aetiology; carcinogenic effects; sarcomas
||literature survey; epidemiologic study; mortality
||D - Periodical articles
|Country / State or Province||USA|
||Toxic and dangerous substances
|Broad subject area(s)