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Document ID (ISN)60733
CIS number 93-1604
ISSN - Serial title 0002-8894 - American Industrial Hygiene Association Journal
Year 1992
Convention or series no.
Author(s) Lundqvist G.R., Yamagiwa M., Pedersen O.F., Nielsen G.D.
Title Inhalation of diethylamine - Acute nasal effects and subjective response
Bibliographic information Mar. 1992, Vol.53, No.3, p.181-185. Illus. 19 ref.
Abstract Adult volunteers were exposed to 25ppm (75mg/m3) diethylamine in a climate chamber for 15min in order to study the acute nasal reactions to an exposure equivalent to the present threshold limit value short-term exposure limit. Changes in nasal volume and nasal resistance were measured by acoustic rhinometry and by rhinomanometry. Acute change in nasal volume, usually seen as acute nasal mucosa response to thermal stimuli, was not observed, nor was an acute change in nasal airway resistance. In a subsequent experiment, the aim was to measure acute sensory effects. Exposure to a concentration increasing from 0 to 12ppm took place for 60min, equal to an average concentration of 10ppm (30mg/m3). A moderate to strong olfactory response and distinct nasal and eye irritation were observed. In spite of considerable individual variation, the results were in agreement with sensory effect estimates obtained from animal studies.
Descriptors (primary) nose; biological effects; diethylamine
Descriptors (secondary) threshold limit values; emergency exposure limits; inhalation tests; irritation; climate chamber studies; eye irritation
Document type D - Periodical articles
Country / State or ProvinceDenmark
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Aliphatic amines