|Document ID (ISN)||60522|
|ISSN - Serial title
||0340-0131 - International Archives of Occupational and Environmental Health
|Convention or series no.
||Urinary excretion of o-cresol and hippuric acid after toluene exposure in rotogravure printing
||1992, Vol.63, No.6, p.377-381. 25 ref.
||In 62 male rotogravure printers, the time-weighted average (TWA) toluene exposure during one workweek ranged from 8 to 496mg/m3 (median 96). Post-shift urinary excretion of hippuric acid showed a poor correlation with the air toluene concentration. Level of o-cresol excretion ranged from 0.08 to 2.37mmol/mol creatinine and was associated with the exposure (rs=0.57, p<0.0001), although the variation was considerable. However, this metabolite was significantly influenced by smoking habits, both in the worker and in 21 unexposed controls. The excretion of these metabolites was followed during vacation, when the workers were unexposed. After 2-4 weeks of vacation, the concentration of o-cresol was significantly higher for the smokers than the non-smokers (0.14 vs 0.06mmol/mol creatinine). No smoking-associated difference was found for the urinary hippuric acid concentration. However, there was an association between alcohol consumption and hippuric acid excretion (p=0.003); no such difference was shown for o-cresol. These results demonstrate that hippuric acid and o-cresol excretion are unsuitable for biological monitoring of toluene exposure when the exposure level is below 200mg/m3.
||printing industry; biochemical tests; exposure evaluation; toluene
||4-chloro-o-cresol; determination in urine; urinary metabolites; hippuric acid
||D - Periodical articles
|Country / State or Province||Sweden|
||Toxic and dangerous substances
|Broad subject area(s)
||Printing, photography and photocopying industry