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Document ID (ISN)60522
CIS number 93-1264
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 1992
Convention or series no.
Author(s) Nise G.
Title Urinary excretion of o-cresol and hippuric acid after toluene exposure in rotogravure printing
Bibliographic information 1992, Vol.63, No.6, p.377-381. 25 ref.
Abstract In 62 male rotogravure printers, the time-weighted average (TWA) toluene exposure during one workweek ranged from 8 to 496mg/m3 (median 96). Post-shift urinary excretion of hippuric acid showed a poor correlation with the air toluene concentration. Level of o-cresol excretion ranged from 0.08 to 2.37mmol/mol creatinine and was associated with the exposure (rs=0.57, p<0.0001), although the variation was considerable. However, this metabolite was significantly influenced by smoking habits, both in the worker and in 21 unexposed controls. The excretion of these metabolites was followed during vacation, when the workers were unexposed. After 2-4 weeks of vacation, the concentration of o-cresol was significantly higher for the smokers than the non-smokers (0.14 vs 0.06mmol/mol creatinine). No smoking-associated difference was found for the urinary hippuric acid concentration. However, there was an association between alcohol consumption and hippuric acid excretion (p=0.003); no such difference was shown for o-cresol. These results demonstrate that hippuric acid and o-cresol excretion are unsuitable for biological monitoring of toluene exposure when the exposure level is below 200mg/m3.
Descriptors (primary) printing industry; biochemical tests; exposure evaluation; toluene
Descriptors (secondary) 4-chloro-o-cresol; determination in urine; urinary metabolites; hippuric acid
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Printing, photography and photocopying industry
Exposure evaluation
Aromatic hydrocarbons