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Document ID (ISN)60137
CIS number 93-903
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1991
Convention or series no.
Author(s) Lundh T., Stňhlbom B., ┼kesson B.
Title Dimethylamine in mould core manufacturing: Exposure, metabolism and biological monitoring
Bibliographic information Mar. 2791, Vol.48, No.3, p.203-207. 27 ref. Illus.
Abstract Exposure to dimethylethylamine (DMEA) and metabolism of the substance were studied in 12 mould core makers in four foundries that use the Ashland cold box technique. The mean time weighted average (TWA) full work shift DMEA exposure concentration was 3.7mg/m3. Inhaled DMEA was excreted into urine as the original amine and as its metabolite dimethylethylamine-N-oxide (DMEAO). This metabolite made up a median of 87 (range 18-93)% of the sum of DMEA and DMEAO concentrations excreted into the urine. Occupational exposure did not significantly increase the urinary excretion of dimethylamine or methylethylamine. The data indicate half lives after the end of exposure for DMEA in urine of 1.5h and DMEAO of 3h. Postshift summed concentration of DMEA and DMEAO in plasma and urine is a good indicator of the TWA concentration in air during the workday, and might thus be used for biological monitoring. An air concentration of 10mg/m3 corresponds to a urinary excretion of the summed amount of DMEA and DMEAO of 135 mmol/mol creatinine.
Descriptors (primary) metabolic process; ethyldimethylamine; foundries; moulding and coremaking; exposure tests; aliphatic amines
Descriptors (secondary) half life; determination in urine; determination in blood; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Foundries, metalcasting and forging operations
Biological monitoring
Aliphatic amines