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CISDOC database

Document ID (ISN)60064
CIS number 93-913
ISSN - Serial title 0096-1736 - Journal of Occupational Medicine
Year 1992
Convention or series no.
Author(s) Schecter A., Ryan J.J.
Title Persistent brominated and chlorinated dioxin blood levels in a chemist 35 years after dioxin exposure
Bibliographic information July 1992, Vol.34, No.7, p.702-707. 38 ref.
Abstract In this case study a chemist, after synthesising 10g of 2,3,7,8-tetrabromodibenzodioxin (TBrDD), suffered from mild and transient chloracne of the neck and wrists. Later in the year (September 1956), after synthesising 16g of 2,3,7,8-tetrachlorodibenzodioxin (TCDD), he suffered severe chloracne of the entire body, headaches, backache, and leg pain on exertion. His measured 2,3,7,8-TBrDD in 1991 was 625 parts per trillion (ppt) in whole blood lipid, 35 years after initial exposure and 18ppt TCDD, an elevated level in comparison with the mean 2,3,7,8-TCDD level of 5ppt in the US population. This is the first reported detection of a brominated dioxin in human tissue. The total halogenated dioxin body burden in September 1956 is estimated to have been between 13,005ppt and 146,726ppt. This uptake demonstrates an occupational hazard to chemists and chemical workers, and the usefulness of human tissue dioxin measurements to document absorption.
Descriptors (primary) chlorinated dibenzodioxins; laboratory work; tetrachlorodibenzodioxin; long-term exposure; dioxins; chloracne; tetrabromodibenzodioxin
Descriptors (secondary) determination in blood; case study
Document type D - Periodical articles
Country / State or ProvinceCanada; USA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Heterocyclic compounds
Skin diseases