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Document ID (ISN)59993
CIS number 93-511
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 1992
Convention or series no.
Author(s) Eisen E.A., Tolbert P.E., Monson R.R., Smith T.J.
Title Mortality studies of machining fluid exposure in the automobile industry - I. A standardized mortality ratio analysis
Bibliographic information Dec. 1992, Vol.22, No.6, p.809-824. 29 ref.
Abstract This cohort study was initiated to assess whether long-term exposure to machining fluids in the course of machining, grinding, and other cutting operations is associated with excess cancer mortality. The cohort includes more than 45,000 automobile production workers from three plants, almost one million years of follow-up, over 10,000 deaths, and an extensive exposure assessment component. Standardised mortality ratios (SMRs) were estimated for each of the three plants, using both US and local populations as reference. Relative risks of 1.2-3.1 were observed for several specific respiratory and digestive cancers, including cancer of the stomach, large intestine, pancreas, lung, and larynx. Elevated risks for leukaemia and asthma were also noted. Future exposure-response analyses will provide the opportunity to identify relatively modest excesses in cause-specific mortality risk associated with exposure to specific types (straight, soluble, or synthetic), additives, or components of machining fluids.
Descriptors (primary) mortality; exposure; motor vehicle industry; cutting fluids
Descriptors (secondary) leukaemia; occupational diseases; laryngeal cancer; asthma; neoplasms; tumour of the pancreas; gastrointestinal cancer; epidemiologic study; lung cancer
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Metal production and metalworking
Broad subject area(s) Industries and occupations
Browse category(ies) Motor vehicle manufacturing industry