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Document ID (ISN)59322
CIS number 93-239
ISSN - Serial title 0105-1873 - Contact Dermatitis
Year 1992
Convention or series no.
Author(s) Damstra R.J., van Vloten W.A., van Ginkel C.J.W.
Title Allergic contact dermatitis from the preservative 1,2-benzisothiazolin-3-one (1,2-BIT; Proxel«): A case report, its prevalence in those occupationally at risk and in the general dermatological population, and its relationship to allergy to its analogue Kathon« CG
Bibliographic information Aug. 1992, Vol.27, No.2, p.105-109. Illus. 17 ref.
Abstract Occupational contact allergy to 1,2-benzisothiazolin-3-one (1,b-BIT, Proxel«) is analysed. This compound is widely used in industry as a preservative in water-based solutions such as pastes, paints and cutting oils. The optimal concentration for patch testing proved to be 0.4g/L (0.04%) in water. In 4 out of 17 patients (23%) at occupational risk (painters, paper-hangers), contact allergy to 1,2-BIT was found. Of 556 consecutive dermatological patients without clear occupational risk, 10 (1.8%) showed positive patch tests to 1,2-BIT; in 3 patients 1,2-BIT contact allergy was related to domestic paper-hanging. Although the chemical structure of 1,2-BIT shows some analogy with the preservative Kathon« CG true cross-sensitivity was found to be unlikely.
Descriptors (primary) 1,2-benzisothiazolin-3-one; morbidity; preservatives; painting; exposure evaluation; eczema
Descriptors (secondary) paints; skin tests; cutting fluids; skin allergies
Document type D - Periodical articles
Country / State or ProvinceNetherlands
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Skin diseases
Heterocyclic compounds
Surface treatment
Exposure evaluation