|
|
 |
|
|
CISDOC database
| Document ID (ISN) | 59322 |
| CIS number |
93-239 |
| ISSN - Serial title |
0105-1873 - Contact Dermatitis |
| Year |
1992 |
| Convention or series no. |
|
| Author(s) |
Damstra R.J., van Vloten W.A., van Ginkel C.J.W. |
| Title |
Allergic contact dermatitis from the preservative 1,2-benzisothiazolin-3-one (1,2-BIT; Proxel®): A case report, its prevalence in those occupationally at risk and in the general dermatological population, and its relationship to allergy to its analogue Kathon® CG |
| Bibliographic information |
Aug. 1992, Vol.27, No.2, p.105-109. Illus. 17 ref. |
| Abstract |
Occupational contact allergy to 1,2-benzisothiazolin-3-one (1,b-BIT, Proxel®) is analysed. This compound is widely used in industry as a preservative in water-based solutions such as pastes, paints and cutting oils. The optimal concentration for patch testing proved to be 0.4g/L (0.04%) in water. In 4 out of 17 patients (23%) at occupational risk (painters, paper-hangers), contact allergy to 1,2-BIT was found. Of 556 consecutive dermatological patients without clear occupational risk, 10 (1.8%) showed positive patch tests to 1,2-BIT; in 3 patients 1,2-BIT contact allergy was related to domestic paper-hanging. Although the chemical structure of 1,2-BIT shows some analogy with the preservative Kathon® CG true cross-sensitivity was found to be unlikely. |
| Descriptors (primary) |
1,2-benzisothiazolin-3-one; morbidity; preservatives; painting; exposure evaluation; eczema |
| Descriptors (secondary) |
paints; skin tests; cutting fluids; skin allergies |
| Document type |
D - Periodical articles |
| Country / State or Province | Netherlands |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Surface treatment
Exposure evaluation
Skin diseases
Heterocyclic compounds
|
|
|
|
|
|
