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CISDOC database

Document ID (ISN)59073
CIS number 92-1986
ISSN - Serial title Journal of the National Cancer Institute
Year 1992
Convention or series no.
Author(s) Smith A.H., Patterson D.G., Warner M.L., MacKenzie R., Needham L.L.
Title Serum 2,3,7,8-tetrachlorodibenzo-p-dioxin levels of New Zealand pesticide applicators and their implication for cancer hypotheses
Bibliographic information 15 Jan. 1992, Vol.84, No.2, p.104-108. Illus. 40 ref.
Abstract The phenoxyherbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) is a widely used pesticide. Little is known about the extent of exposure to the 2,4,5-T contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a potent animal carcinogen. The study determined whether the blood serum levels of TCDD in 2,4,5-T applicators were greater than those of a control group not involved in 2,4,5-T spraying. Nine of 548 New Zealand applicators were selected who had sprayed 2,4,5-T for a range of 83-372 months. Results showed that the average serum level of TCDD for applicators was almost 10 times that of the control subjects, while the average levels of all other congeners and isomers measured in the two groups did not differ substantially. Increased risks of cancer from brief exposure to phenoxy herbicides reported in other countries are probably not attributable to the TCDD that contaminates 2,4,5-T. It cannot be determined from these results, however, whether TCDD exposure from prolonged use of 2,4,5-T poses significant health risks.
Descriptors (primary) herbicides; trichlorophenoxyacetic acid; determination in blood; pesticides; long-term exposure; tetrachlorodibenzodioxin
Descriptors (secondary) New Zealand; neoplasms; serum changes
Document type D - Periodical articles
Country / State or ProvinceNew Zealand; USA
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s) Chemical safety
Browse category(ies) Heterocyclic compounds
Agricultural chemicals