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CISDOC database

Document ID (ISN)58802
CIS number 92-1628
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1991
Convention or series no.
Author(s) Ruijten M.W.M.M., Verberk M.M., SallÚ H.J.A.
Title Nerve function in workers with long term exposure to trichloroethene
Bibliographic information Feb. 1991, Vol.48, No.2, p.87-92. Illus. 19 ref.
Abstract Certain functions of the nervous system were compared between 31 printing workers (mean age 44) exposed to trichloroethene (trichloroethylene) (mean duration 16 years) and 28 controls (mean age 45). The mean cumulative exposure of the exposed workers was 704ppm x years. For the assessment of the exposure effect relation a multiple linear regression model was used. In the sural nerve the conduction velocity was reduced and the refractory period was prolonged. The latency of masseter, but not of the blink reflex, was increased. No impairment was found in the functions of motor and autonomic nerves. Thus, refractory period may be a sensitive indicator of preclinical toxic neuropathies. Long-term exposure to trichloroethene at threshold limit values (about 35ppm) may slightly affect the trigeminal and sural nerves.
Descriptors (primary) neurotoxic effects; long-term exposure; trichloroethylene; printing industry
Descriptors (secondary) nervous function tests; cumulative properties; heart rate monitoring; conduction velocity
Document type D - Periodical articles
Country / State or ProvinceNetherlands
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Printing, photography and photocopying industry
Diseases of the nervous system
Halogenated hydrocarbons