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CISDOC database
| Document ID (ISN) | 57404 |
| CIS number |
92-224 |
| ISSN - Serial title |
0140-6736 - Lancet |
| Year |
1991 |
| Convention or series no. |
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| Author(s) |
Saracci R., Kogevinas M., Bertazzi P., Bueno de Mesquita B.H., Coggon D., Green L.M., Kauppinen T., L'Abbé K.A., Littorin M., Lynge E., Mathews J.D., Neuberger M., Osman J., Pearce N., Winkelmann R. |
| Title |
Cancer mortality in workers exposed to chlorophenoxy herbicides and chlorophenols |
| Bibliographic information |
26 Oct. 1991, Vol.338, No.8774, p.1027-1032. 35 ref. |
| Abstract |
This paper reports a historical cohort study of mortality in an international register of 18,910 chlorophenoxy herbicide production workers or sprayers from 10 countries. Exposure was reconstructed through questionnaires, factory or spraying records and job histories. A non-significant increase, based on 4 observed deaths, was noted for soft-tissue sarcoma. Increased risks were found for some uncommon neoplasms, but results are difficult to interpret because of the small numbers. The excess of soft-tissue sarcomas among sprayers is compatible with a causal role of chlorophenoxy herbicides but the excess does not seem to be specifically associated with those herbicides probably contaminated by the toxic dioxin TCDD. |
| Descriptors (primary) |
herbicides; neoplasms; health hazards; chlorophenols |
| Descriptors (secondary) |
chloromethylphenoxyacetic acid; 2,4,6-trichlorophenol; silvex; 4-(2,4-dichlorophenoxy)butanoic acid; phenoxybutyric acid; 2,3,4,6-tetrachlorophenol; pentachlorophenol; dichlorophenoxyacetic acid; trichlorophenoxyacetic acid; tetrachlorodibenzodioxin; sarcomas; epidemiologic study; 2,4-dichlorophenol; trichlorophenol; dichlorprop |
| Document type |
D - Periodical articles |
| Country / State or Province | Australia; Austria; Canada; Denmark; Finland; France; United Kingdom; Italy; Netherlands; New Zealand; Sweden |
| Subject(s) |
Occupational pathology
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| Broad subject area(s) |
Chemical safety
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| Browse category(ies) |
Agricultural chemicals
Phenols and phenolic compounds
Alcohols
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