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CISDOC database

Document ID (ISN)57266
CIS number 92-190
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1990
Convention or series no.
Author(s) Andersson N., Ajwani M.K., Mahashabde S., Tiwari M.K., Kerr Muir M., Mehra V., Ashiru K., Mackenzie C.D.
Title Delayed eye and other consequences from exposure to methyl isocyanate: 93% follow up of exposed and unexposed cohorts in Bhopal
Bibliographic information Aug. 1990, Vol.47, No.8, p.553-558. 16 ref.
Abstract A follow-up study 3 years after exposure to methyl isocyanate in 93% of exposed survivors and "control" residents in 10 Bhopali communities showed an excess of eye irritation, eyelid infection, cataract, and a decrease in visual acuity among the exposed people. Breathlessness was twice as common in the heavily exposed clusters as among those with lower exposure a trend that could not be explained by different age or smoking patterns. Case referent analysis of outpatient attendances at Bhopal Eye Hospital, considering patients with severe refractive errors and astigmatism as "controls", showed a 40% increased risk of trachoma, 36% increased risk of other lid infections, and 45% increased risk of irritant symptoms among previously exposed people. "Bhopal eye syndrome" may thus include resolution of the initial interpalpebral superficial erosion, a subsequent increased risk of eye infections, hyperresponsive phenomena (irritation, watering, and phlyctens), and possibly cataracts. It remains to be confirmed whether this reflects a more generalised disease as a consequence of previous exposure to methyl isocyanate or whether it is only the eye that is affected.
Descriptors (primary) diseases of eyes and related structures; methyl isocyanate; health hazards; delayed effects; cataractogenic effects
Descriptors (secondary) cataract; comparative study; long-term study; amblyopia
Document type D - Periodical articles
Country / State or ProvinceUnited Kingdom; India; USA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Cyano compounds
Diseases of the eye and vision damage
Isocyanates