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CISDOC database

Document ID (ISN)57254
CIS number 92-219
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1990
Convention or series no.
Author(s) Sherson D., Sabro P., Sigsgaard T., Johansen F., Autrup H.
Title Biological monitoring of foundry workers exposed to polycyclic aromatic hydrocarbons
Bibliographic information July 1990, Vol.47, No.7, p.448-453. Illus. 37 ref.
Abstract This investigation describes benzo(a)pyrene (BP) serum protein adduct concentrations in 45 foundry workers and 45 matched non-occupationally exposed controls. High and low BP exposure groups were defined using breathing zone hygienic samples for both quartz and BP exposures. A newly developed enzyme linked immunosorbent assay detected benzo(a)pyrenediolepoxide-I binding to serum protein. Mean BP protein adduct concentrations (SD) for non-smoking and smoking foundry workers were significantly higher than mean values for non-smoking and smoking controls. Foundry workers with high exposures to either quartz or BP had slightly raised mean adduct concentrations compared with foundry workers with low exposure for quartz or BP. Highest mean adduct concentrations were found among a small group of workers with simultaneous high exposures to both quartz and BP suggesting an additive effect. These data support the presence of a possible aetiological connection between an increased risk of lung cancer and BP exposure among foundry workers, and of an additive effect between BP and quartz. Measurement of BP serum protein adduct concentrations appears to be a useful method by which groups exposed to BP may be biologically monitored.
Descriptors (primary) aromatic hydrocarbons; silica; foundries; exposure tests; polycyclic hydrocarbons
Descriptors (secondary) lung cancer; benzo(a)pyrene; biochemical tests; synergism; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceDenmark
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Foundries, metalcasting and forging operations
Biological monitoring
Polycyclic hydrocarbons
Aromatic hydrocarbons