|Document ID (ISN)||56736|
|ISSN - Serial title
||0003-9896 - Archives of Environmental Health
|Convention or series no.
||Sakai T., Araki T., Ushio K.
||Accumulation of erythrocyte nucleotides and their pattern in lead workers
||Sep.-Oct. 1990, Vol.45, No.5, p.273-277. Illus. 12 ref.
||Nucleotides in erythrocytes of lead-exposed subjects were analysed by high-performance liquid chromatography (HPLC). Most of the pyrimidine levels correlated well with blood lead concentrations (Pb-B) and pyrimidine 5'-nucleotidase (P5N) activity. Highly significant correlations were found between Pb-B and uridine 5'-diphosphate-glucose (UDPG), cytidine 5'-triphosphate (CTP), or CDP-choline (CDPC). The levels of these compounds were sharply elevated when P5N activity was reduced to levels less than 7Ámole/h.g haemoglobin (Hb), which corresponded to a Pb-B of 60Ág/100g. Therefore, concentration of these nucleotides may provide a useful index of lead poisoning. Adenosine 5'-triphosphate (ATP) concentrations were correlated negatively with Pb-B, whereas adenosine 5'-monophosphate (AMP) concentrations were correlated positively with Pb-B. These results suggest that lead affects not only pyrimidine nucleotide metabolism but also purine nucleotide metabolism (the energy production system).
||nucleotides; printing industry; lead; erythrocytes; smelting plants; lead industry; exposure tests
||pyrimidine nucleotidase; haemoglobin monitoring; chronic poisoning
||D - Periodical articles
|Country / State or Province||Japan|
||Toxic and dangerous substances
|Broad subject area(s)
Lead and compounds
Printing, photography and photocopying industry
Smelting and refining operations