|Document ID (ISN)||55724|
|ISSN - Serial title
||0025-7818 - Medicina del lavoro
|Convention or series no.
||Clonfero E., Venier P., Granella M., Levis A.G.
||Identification of genotoxic compounds used in the leather processing industry
||Identificazione di composti genotossici utilizzati nella lavorazione delle pelli [in Italian]|
||May-June 1990, Vol.81, No.3, p.212-221. 45 ref.
||The release of mutagens from 7 carbon black-based leather dyes and from leather samples at various stages of finishing was determined. After vigorous treatment with toluene, 4 commercial dyes yielded mutagenic extracts on Salmonella typhimurium in the presence of microsomal enzymes. Only one of the responsible chemicals was a polycyclic aromatic hydrocarbon. The low bioavailability of mutagens contained in carbon black and their low mutagenic activity suggest that the risk associated with the use of these dyes is probably negligible. Ethanol extracts of finished leather were mutagenic in the absence of S9 mix. Analysis of extracts of leather samples at various stages of processing showed that mutagenic activity was detectable after the colouring process. The responsible compound was a nitroazo dye, C.I. Acid Brown 83. 18 commercial tannins containing mainly Cr(III) sulfates were assessed for genotoxicity. Most were contaminated with Cr(VI), a known mugaten and carcinogen, at levels sufficient to include sister chromatid exchanges in mammalian cells.
||mutagenic effects; mutagens; leather goods industry; tanning industry; dyes
||aromatic hydrocarbons; Acid Brown 83; mutagenicity tests; carbon black; polycyclic hydrocarbons; azo compounds
||D - Periodical articles
|Country / State or Province||Italy|
||Toxic and dangerous substances
|Broad subject area(s)
||Footwear, leather and fur industry
Genetic factors in reaction to exposures
Antifertility and prenatal effects