ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)55724
CIS number 91-537
ISSN - Serial title 0025-7818 - Medicina del lavoro
Year 1990
Convention or series no.
Author(s) Clonfero E., Venier P., Granella M., Levis A.G.
Title Identification of genotoxic compounds used in the leather processing industry
Original title Identificazione di composti genotossici utilizzati nella lavorazione delle pelli [in Italian]
Bibliographic information May-June 1990, Vol.81, No.3, p.212-221. 45 ref.
Abstract The release of mutagens from 7 carbon black-based leather dyes and from leather samples at various stages of finishing was determined. After vigorous treatment with toluene, 4 commercial dyes yielded mutagenic extracts on Salmonella typhimurium in the presence of microsomal enzymes. Only one of the responsible chemicals was a polycyclic aromatic hydrocarbon. The low bioavailability of mutagens contained in carbon black and their low mutagenic activity suggest that the risk associated with the use of these dyes is probably negligible. Ethanol extracts of finished leather were mutagenic in the absence of S9 mix. Analysis of extracts of leather samples at various stages of processing showed that mutagenic activity was detectable after the colouring process. The responsible compound was a nitroazo dye, C.I. Acid Brown 83. 18 commercial tannins containing mainly Cr(III) sulfates were assessed for genotoxicity. Most were contaminated with Cr(VI), a known mugaten and carcinogen, at levels sufficient to include sister chromatid exchanges in mammalian cells.
Descriptors (primary) mutagenic effects; mutagens; leather goods industry; tanning industry; dyes
Descriptors (secondary) aromatic hydrocarbons; Acid Brown 83; mutagenicity tests; carbon black; polycyclic hydrocarbons; azo compounds
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Footwear, leather and fur industry
Genetic factors in reaction to exposures