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CISDOC database

Document ID (ISN)54976
CIS number 90-2005
ISBN(s) 91-7045-037-4
Year 1989
Convention or series no. Arbete och hälsa 1989:25
Author(s) Garberg P., Högberg J., Lundberg I., Lundberg P.
Title NIOH and NIOSH basis for an occupational health standard: Di(2-ethylhexyl)phthalate (DEHP)
Bibliographic information Arbetsmiljöinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1989. Also available from: Superintendent of Documents, US Government Printing Office, Washington D.C. 20402, USA. 53p. 131 ref.
Abstract Literature survey on di(2-ethylhexyl)phthalate (DEHP), to be used as background information for discussions on occupational exposure limits in the USA and Sweden. Data on occupational exposure levels and effects on humans are limited. DEHP is hydrolysed to the monoethylhexyl product and further oxidised. No accumulation has been observed. DEHP has a low acute toxicity. Long-term exposure to rats causes testicular atrophy. DEHP is carcinogenic and teratogenic in rodents. Most genotoxicity tests have been negative. However, certain tests have indicated that DEHP may affect the genome in vitro.
Descriptors (primary) bis(ethylhexyl) phthalate; limitation of exposure; toxicology
Descriptors (secondary) literature survey; Sweden; USA; testicular atrophy; criteria document; genetic effects; teratogenic effects; carcinogenic effects; determination of exposure limits
Document type F - Information notes, codes of practice, standards
Country / State or ProvinceSweden; USA
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Genetic factors in reaction to exposures
Phthalates
Esters and salts