ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)52977
CIS number 89-1941
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1989
Convention or series no.
Author(s) Nise G., Attewell R., Skerfving S., ěrbaek P.
Title Elimination of toluene from venus blood and adipose tissue after occupational exposure
Bibliographic information June 1989, Vol.46, No.6, p.407-411. 18 ref. Illus.
Abstract In a group of 37 rotogravure printers a close correlation was found between the time weighted toluene exposure during a five day working week (range 8-416mg/m3, median 75) and the concentration of toluene in subcutaneous adipose tissue (range 1.1-20.7mg/kg, median 3.8). After exposure ceased, the elimination of toluene was followed up in 11 subjects. The toluene concentration in venous blood decreased non-linearly and the elimination curves contained at least three exponential components. The first two had median estimated half times of nine minutes and two hours respectively. The third component, with a median half time of 90 hours, reflected the decline in adipose tissue, which had a median half time of 79 hours. The study showed protracted endogenous toluene exposure from adipose tissue depots long after the end of exogenous exposure. The observations also suggest that the blood toluene concentrations on Monday mornings might be used as an index of exposure during the previous week.
Descriptors (primary) toluene; length of exposure; photogravure printing; determination in tissues; determination in blood
Descriptors (secondary) blood monitoring; exposure tests
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Aromatic hydrocarbons
Printing, photography and photocopying industry