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CISDOC database

Document ID (ISN)52976
CIS number 89-1940
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1989
Convention or series no.
Author(s) Ratcliffe J.M., Schrader S.M., Clapp D.E., Halperin W.E., Turner T.W., Hornung R.W.
Title Semen quality in workers exposed to 2-ethoxyethanol
Bibliographic information June 1989, Vol.46, No.6, p.399-406. 34 ref.
Abstract To evaluate whether long term exposure to 2-ethoxyethanol (2EE) may affect semen quality, a cross sectional study was conducted among men exposed to 2EE used as a binder slurry in a metal castings process. Because of the potential for substantial absorption of 2EE through skin exposure, urine measurements of the metabolite of 2EE, 2-ethoxyacetic acid (2EAA) were conducted showing levels of 2EAA ranging from non-detectable to 163mg 2EAA/g creatinine. The average sperm count per ejaculate among the workers exposed to 2EE was significantly lower than that of the unexposed group after consideration of abstinence, sample age, subjects' age, tobacco, alcohol and caffeine use, urogenital disorders, fever, and other illnesses. The mean sperm concentrations of the exposed and unexposed groups did not significantly differ from each other. No effect of exposure to 2EE on semen volume, sperm viability, motility, velocity, and normal morphology or testicular volume was detected, although some differences in the proportion of abnormal sperm shapes were observed. These data suggest that there may be an effect of 2EE on sperm count among these workers, although the possibility that other factors may be affecting the semen quality in both exposed and unexposed men in this population or that the results reflect bias introduced by the low participation rates cannot be excluded.
Descriptors (primary) ethoxyethanol; long-term exposure; spermatogenic disturbances; casting of metals
Descriptors (secondary) questionnaire survey; metabolic process
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the reproductive system
Glycol ethers
Foundries, metalcasting and forging operations