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CISDOC database

Document ID (ISN)52974
CIS number 89-1939
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1989
Convention or series no.
Author(s) Araki S., Aono H.
Title Effect of water restriction and water loading on daily urinary excretion of heavy metals and organic substances in metal workers
Bibliographic information June 1989, Vol.46, No.6, p.389-392. 18 ref. Illus.
Abstract The effects of urinary volume on daily urinary excretion of seven heavy metals and four organic substances were examined in relation to the changes in their plasma and erythrocyte concentrations and urinary creatinine excretion in 19 metal workers. The examination was conducted under the conditions of water restriction and loading for six days. The major findings were as follows: (1) urinary excretion of all heavy meatals and organic substances except mercury, together with creatinine excretion, significantly decreased under conditions of water restriction whereas under conditions of water loading their excretion increased significantly; (2) daily variations in urinary excreton of lead, cadmium, chromium, copper, hippuric acid, δ-aminolaevulinic acid, and coproporphyrin did not differ significantly from the variation in urinary excretion of creatinine. It is suggested that glomerular filtration is the major factor determining renal excretory mechanisms of the substances examined.
Descriptors (primary) organic compounds; metals; foundries; water deprivation; urinary excretion
Descriptors (secondary) statistical evaluation; comparative study; creatinine excretion; exposure tests
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Foundries, metalcasting and forging operations
Inorganic substances