Document ID (ISN) | 51346 |
CIS number |
89-566 |
ISSN - Serial title |
0007-1072 - British Journal of Industrial Medicine |
Year |
1988 |
Convention or series no. |
|
Author(s) |
Campbell L., Wilson H.K., Samuel A.M., Gompertz D. |
Title |
Interactions of m-xylene and aspirin metabolism in man |
Bibliographic information |
Feb. 1988, Vol.45, No.2, p.127-132. Illus. 18 ref. |
Abstract |
The interaction between m-xylene and aspirin was studied on five male volunteers who were exposed to m-xylene by inhalation (100ppm), aspirin (1,500mg) by mouth, and m-xylene and aspirin together under controlled conditions in an exposure chamber. Urine and blood samples were collected and analysed for m-xylene, aspirin, and their metabolites. The amounts of the major glycine conjugates produced from m-xylene (m-methylhippuric acid) and aspirin (salicyluric acid) were significantly reduced by about 50% when m-xylene and aspirin were coadministered. There appears to be a mutual inhibition on the formation of the respective glycine conjugates due to competition for either the enzymes, acyl-CoA synthetase, or glycine N-acylase. These findings have implications in the biological monitoring of workers exposed to m-xylene. |
Descriptors (primary) |
acetylsalicylic acid; m-xylene; exposure tests; synergism; metabolic studies; exposure evaluation |
Descriptors (secondary) |
organic acids; toxic substances; organic solvents; determination in urine; inhibitory effects; inhalation tests; determination in blood; urinary metabolites |
Document type |
D - Periodical articles |
Subject(s) |
Occupational pathology
|
Broad subject area(s) |
Chemical safety
|
Browse category(ies) |
Biological monitoring Aromatic hydrocarbons Organic acids Exposure evaluation
|