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CISDOC database

Document ID (ISN)51346
CIS number 89-566
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1988
Convention or series no.
Author(s) Campbell L., Wilson H.K., Samuel A.M., Gompertz D.
Title Interactions of m-xylene and aspirin metabolism in man
Bibliographic information Feb. 1988, Vol.45, No.2, p.127-132. Illus. 18 ref.
Abstract The interaction between m-xylene and aspirin was studied on five male volunteers who were exposed to m-xylene by inhalation (100ppm), aspirin (1,500mg) by mouth, and m-xylene and aspirin together under controlled conditions in an exposure chamber. Urine and blood samples were collected and analysed for m-xylene, aspirin, and their metabolites. The amounts of the major glycine conjugates produced from m-xylene (m-methylhippuric acid) and aspirin (salicyluric acid) were significantly reduced by about 50% when m-xylene and aspirin were coadministered. There appears to be a mutual inhibition on the formation of the respective glycine conjugates due to competition for either the enzymes, acyl-CoA synthetase, or glycine N-acylase. These findings have implications in the biological monitoring of workers exposed to m-xylene.
Descriptors (primary) acetylsalicylic acid; m-xylene; exposure tests; synergism; metabolic studies; exposure evaluation
Descriptors (secondary) organic acids; toxic substances; organic solvents; determination in urine; inhibitory effects; inhalation tests; determination in blood; urinary metabolites
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring
Aromatic hydrocarbons
Organic acids
Exposure evaluation