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Document ID (ISN)48793
CIS number 87-1426
ISBN(s) 91-7464-239-1
Year 1984
Convention or series no. Arbete och Hälsa 1984:46
Author(s) Kauppinen T.
Title Nordic Expert Group for Documentation of Occupational Exposure Limits - 54. Chlorophenols
Original title Nordiska expertgruppen för gränsvärdesdokumentation - 54. Klorfenoler [in Swedish]
Bibliographic information Arbetarskyddsstyrelsen, Publikationsservice, 171 84 Solna, Sweden, 1984. 59p. Illus. 137 ref.
Abstract The document contains a review and an evaluation of selected literature to be used for setting hygienic standards for the most widely used chlorophenols. Heavy exposure to chlorophenols, especially pentachlorophenol, can cause poisoning which is based on uncoupling of oxidative phosphorylation. Chlorophenols and their salts are irritants. High doses of chlorophenols have been associated with liver damage, aplastic anaemia, and immunosuppressive effects, usually after exposure to technical chlorophenols containing e.g. chlorinated dibenzodioxins and dibenzofurans as impurities. However, both pure and technical penta- or tetrachlorophenol are foetotoxic to rats at low doses. Human data on foetotoxicity are lacking. The most severe hazard reported is the possible carcinogenicity of certain chlorophenols. Four Swedish case-referent studies show an association between chlorophenol exposure and soft tissue sarcomas, malignant lymphomas and cancer of the nose and nasopharynx. Thus, technical chlorophenols should be held as suspected human carcinogens, although the possible risk may be due to the chlorinated dioxin and furan impurities. Hygienic and biological limit values ought to be based on the irritant effects, foetotoxic effects, and possible carcinogenicity of chlorophenols.
Descriptors (primary) embryotoxic effects; threshold limit values; irritants; determination of exposure limits; dioxins; toxicology; chlorophenols; carcinogens
Descriptors (secondary) toxic effects; literature survey; Nordic Countries; metabolic process; 2,4,6-trichlorophenol; pentachlorophenol; animal experiments; criteria document; trichlorophenol; 2,3,4,6-tetrachlorophenol
Document type F - Information notes, codes of practice, standards
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Occupational exposure limits
Phenols and phenolic compounds
Heterocyclic compounds
Alcohols