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CISDOC database
| Document ID (ISN) | 48793 |
| CIS number |
87-1426 |
| ISBN(s) |
91-7464-239-1 |
| Year |
1984 |
| Convention or series no. |
Arbete och Hälsa 1984:46
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| Author(s) |
Kauppinen T. |
| Title |
Nordic Expert Group for Documentation of Occupational Exposure Limits - 54. Chlorophenols |
| Original title |
Nordiska expertgruppen för gränsvärdesdokumentation - 54. Klorfenoler [in Swedish] |
| Bibliographic information |
Arbetarskyddsstyrelsen, Publikationsservice, 171 84 Solna, Sweden, 1984. 59p. Illus. 137 ref. |
| Abstract |
The document contains a review and an evaluation of selected literature to be used for setting hygienic standards for the most widely used chlorophenols. Heavy exposure to chlorophenols, especially pentachlorophenol, can cause poisoning which is based on uncoupling of oxidative phosphorylation. Chlorophenols and their salts are irritants. High doses of chlorophenols have been associated with liver damage, aplastic anaemia, and immunosuppressive effects, usually after exposure to technical chlorophenols containing e.g. chlorinated dibenzodioxins and dibenzofurans as impurities. However, both pure and technical penta- or tetrachlorophenol are foetotoxic to rats at low doses. Human data on foetotoxicity are lacking. The most severe hazard reported is the possible carcinogenicity of certain chlorophenols. Four Swedish case-referent studies show an association between chlorophenol exposure and soft tissue sarcomas, malignant lymphomas and cancer of the nose and nasopharynx. Thus, technical chlorophenols should be held as suspected human carcinogens, although the possible risk may be due to the chlorinated dioxin and furan impurities. Hygienic and biological limit values ought to be based on the irritant effects, foetotoxic effects, and possible carcinogenicity of chlorophenols. |
| Descriptors (primary) |
embryotoxic effects; threshold limit values; irritants; determination of exposure limits; dioxins; toxicology; chlorophenols; carcinogens |
| Descriptors (secondary) |
toxic effects; literature survey; Nordic Countries; metabolic process; 2,4,6-trichlorophenol; pentachlorophenol; animal experiments; criteria document; trichlorophenol; 2,3,4,6-tetrachlorophenol |
| Document type |
F - Information notes, codes of practice, standards |
| Subject(s) |
Toxic and dangerous substances
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| Broad subject area(s) |
Chemical safety
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| Browse category(ies) |
Alcohols
Occupational exposure limits
Phenols and phenolic compounds
Heterocyclic compounds
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