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Document ID (ISN)48768
CIS number 87-1353
ISSN - Serial title 0098-4108 - Journal of Toxicology and Environmental Health
Year 1987
Convention or series no.
Author(s) Governa M., Calisti R., Coppa G., Tagliavento G., Colombi A., Troni W.
Title Urinary excretion of 2,5-hexanedione and peripheral polyneuropathies in workers exposed to hexane
Bibliographic information 1987, Vol.20, No.3, p.219-228. 26 ref.
Abstract 40 shoe factory workers who were exposed to hexane were investigated to see if there was a correlation between electroneuromyographic changes indicative of neuropathy and urinary excretion of the metabolic products of n-hexane and its isomers. 2,5-Hexanedione and γ-valerolactone were discovered in all cases, while 2-hexanol was found in 11 cases. 2,5-Hexanedione was the main metabolite in 39 cases. Metabolic products of cyclohexane were present in about one-fifth of the cases, while trichloroethanol, a metabolic product of trichloroethylene, was nearly always present, all at very low concentrations. Electromyographic abnormalities significant for early detection of toxic polyneuropathy were found in 14 cases. A statistically significant correlation of the electroneuromyographic scoring with the urinary metabolites was observed only for 2,5-hexanedione and γ-valerolactone. Since γ-valerolactone is probably not a true metabolite of n-hexane, the results support the hypothesis that polyneuropathies in shomakers are due to 2,5-hexanedione. For practical purposes the urinary concentration of 2,5-hexanedione can serve as a predictive measurement for early detection of neurotoxic lesions at preclinical stages.
Descriptors (primary) 2,5-hexanedione; hexane; shoe industry; diseases of peripheral nervous system; exposure evaluation; urinary excretion
Descriptors (secondary) gamma-valerolactone; statistical evaluation; electroneuromyography; urinary metabolites
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the nervous system
Exposure evaluation
Aliphatic and alicyclic hydrocarbons
Footwear, leather and fur industry