| Document ID (ISN) | 47284 |
| CIS number |
86-1984 |
| ISSN - Serial title |
0096-1736 - Journal of Occupational Medicine |
| Year |
1986 |
| Convention or series no. |
|
| Author(s) |
Hemstreet G.P., West S.S., Cook M.S. |
| Title |
Improved nuclear fluorescence screening technique |
| Bibliographic information |
Oct. 1986, Vol.28, No.10, p.1004-1010. Illus. 29 ref. |
| Abstract |
Three separate screening studies in the USA have tested the sensitivity and specificity of quantitative fluorescence image analysis for detecting bladder cancer. Nuclear intensity (NI) measurements of fluorescent dye-stained epithelial cells from voided urine and bladder washings were compared with routine Papanicolaou (Pap) cytology results, and findings were verified against pathological biopsy diagnoses. The NI cytology method detected the pathologically confirmed tumours earlier and with greater specificity than did conventional cytology. In the study of 140 clinically symptomatic patients in Oklahoma, the NI method detected 91.1% (3 of 34) of the pathologically confirmed grades 1 and 2 tumours and 100% of 18 grades 3 and 4 tumours. Pap cytology detected only 47% (16 of 34) of low-grade and 78% (14 of 18) of high-grade tumours. Comparable results were obtained in a study of symptomatic patients in Mississipi and the method has been employed in the screening of a high-risk occupationally exposed cohort in Georgia. |
| Descriptors (primary) |
USA; urine cytology; bladder tumour; early diagnosis |
| Descriptors (secondary) |
detection by fluorescence; description of technique |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Diseases of the kidney and the urinary system
|
