| Document ID (ISN) | 46638 |
| CIS number |
86-1355 |
| ISSN - Serial title |
0355-3140 - Scandinavian Journal of Work, Environment and Health |
| Year |
1986 |
| Convention or series no. |
|
| Author(s) |
Jongeneelen F.J., Bos R.P., Anzion R., Theuws J., Henderson P.T. |
| Title |
Biological monitoring of polycyclic aromatic hydrocarbons - Metabolites in urine |
| Bibliographic information |
Apr. 1986, Vol.12, No.2, p.137-143. Illus. 22 ref. |
| Abstract |
Assays of urinary mutagenicity, urinary 3-hydroxybenzo(a)pyrene, and urinary 1-hydroxypyrene were used to study their suitability in estimating exposure to polycyclic aromatic hydrocarbons (PAH) in coal tar products. Experiments on rats showed a significant correlation between coal tar exposure and levels of excreted mutagens and metabolites. Experiments involving 5 dermatologic patients undergoing topical coal tar treatment and smoking workers of a coal tar distillation plant showed that only 1-hydroxypyrene could be used as a sensitive and specific marker for the assessment of occupational exposure to PAH. |
| Descriptors (primary) |
pyrene; coal tar; benzo(a)pyrene; exposure tests; hydroxybenzo(a)pyrenes; urinary metabolites; polycyclic hydrocarbons |
| Descriptors (secondary) |
mutagens; human experiments; animal experiments; exposure evaluation |
| Document type |
D - Periodical articles |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Alcohols
Biological monitoring
Polycyclic hydrocarbons
Aromatic hydrocarbons
|
