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Document ID (ISN)44609
CIS number 85-1606
ISSN - Serial title Gigiena truda i professional'nye zabolevanija
Year 1984
Convention or series no.
Author(s) Germanova A.L., Ajzvert L.G., Šidlovskaja L.N., Mel'nikova L.V., Bidevkina M.V., Domšlak M.G., Katosova L.D.
Title Comparative toxicity, hazardousness and biological action of 4-oxo-2,2,6,6-tetramethylpiperidine and 4-amino-2,2,6,6-tetramethylpiperidine
Original title Sravnitel'naja harakteristika toksičnosti, opasnosti i haraktera biologičeskogo dejstvija na organizm 4-okso-2,2,6,6-tetrametilpiperidina i 4-amino-2,2,6,6-tetrametilpiperidina [in Russian]
Bibliographic information May 1984, No.5, p.53-54.
Abstract The title compounds are starting materials for the synthesis of light stabilisers for polymers. In a standard battery of toxicological tests, both compounds were of low toxicity (intragastric LD50=1539 and 906mg/kg for rats for the oxo and amino compounds, respectively). Substituting the oxo group for the amino group had no effect on the toxicity or biological action of tetramethylpiperidine. A provisional exposure limit of 3mg/m3 for both compounds has been recommended and accepted.
Descriptors (primary) threshold limit values; USSR; chemical industry; 4-amino-2,2,6,6-tetramethylpiperidine; stabilizers; toxicology; plastics industry; 4-oxo-2,2,6,6-tetramethylpiperidine
Descriptors (secondary) animal experiments
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Occupational exposure limits
Heterocyclic compounds
Plastics industry
Chemical industry