|Document ID (ISN)||44608|
|ISSN - Serial title
||Gigiena truda i professional'nye zabolevanija
|Convention or series no.
||Tatevosjan A.Ė., Sahkaljan Ė.O.
||Experimental bases for a MAC for the acaricide Plictran in workplace air
||Materialy k ėksperimental'nomu obosnovaniju PDK akaricida pliktrana v vozduhe rabočej zony [in Russian]|
||May 1984, No.5, p.52-53. 5 ref.
||A standard battery of toxicological tests showed Plictran (tricyclohexyltin hydroxide) to be moderately toxic: intragastric LD50=318, 275 and 458mg/kg for rats, mice and rabbits, respectively; topical LD50 = 1880 and 2422mg/kg for rats and rabbits respectively; inhalation CL50=244 and 290mg/m3 for rats and mice, respectively. The threshold of acute toxicity (kidney damage) was about 6.5mg/m3. Plictran was not allergenic or sensitising, but was an irritant. Chronic exposure to 0.170mg/m3 did not produce embryotropic or teratogenic effects; this concentration may be taken as a threshold for such effects. A MAC of 0.02mg/m3 should be established for Plictran production facilities; the standard should carry the warning "skin absorption".
||threshold limit values; irritants; USSR; renal damage; acaricides; toxicology; tricyclohexyltin hydroxide
||D - Periodical articles
||Toxic and dangerous substances
|Broad subject area(s)
||Diseases of the kidney and the urinary system
Occupational exposure limits