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Document ID (ISN)44608
CIS number 85-1605
ISSN - Serial title Gigiena truda i professional'nye zabolevanija
Year 1984
Convention or series no.
Author(s) Tatevosjan A.Ė., Sahkaljan Ė.O.
Title Experimental bases for a MAC for the acaricide Plictran in workplace air
Original title Materialy k ėksperimental'nomu obosnovaniju PDK akaricida pliktrana v vozduhe rabočej zony [in Russian]
Bibliographic information May 1984, No.5, p.52-53. 5 ref.
Abstract A standard battery of toxicological tests showed Plictran (tricyclohexyltin hydroxide) to be moderately toxic: intragastric LD50=318, 275 and 458mg/kg for rats, mice and rabbits, respectively; topical LD50 = 1880 and 2422mg/kg for rats and rabbits respectively; inhalation CL50=244 and 290mg/m3 for rats and mice, respectively. The threshold of acute toxicity (kidney damage) was about 6.5mg/m3. Plictran was not allergenic or sensitising, but was an irritant. Chronic exposure to 0.170mg/m3 did not produce embryotropic or teratogenic effects; this concentration may be taken as a threshold for such effects. A MAC of 0.02mg/m3 should be established for Plictran production facilities; the standard should carry the warning "skin absorption".
Descriptors (primary) threshold limit values; irritants; USSR; renal damage; acaricides; toxicology; tricyclohexyltin hydroxide
Descriptors (secondary) animal experiments
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Diseases of the kidney and the urinary system
Agricultural chemicals
Occupational exposure limits