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CISDOC database

Document ID (ISN)43881
CIS number 85-759
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1984
Convention or series no.
Author(s) Mutti A., Falzoi M., Lucertini S., Arfini G., Zignani M., Lombardi S., Franchini I.
Title n-Hexane metabolism in occupationally exposed workers
Bibliographic information Nov. 1984, Vol.41, No.4, p.533-538. Illus. 16 ref.
Abstract This study was conducted on 10 workers in a shoe factory. The n-hexane concentrations in the workplace air ranged from 8-1143mg/m3 over 8h, with a median concentration of 243mg/m3. Alveolar retention of n-hexane was about 25%, corresponding to a lung uptake of 17%. Post-exposure alveolar excretion (monitored for 6h) was about 10% of the total uptake. The main metabolites of n-hexane were determined in urine samples collected before, at the end, and 15h after the work shift. Urinary concentrations were low, though related to original n-hexane concentrations in air. The best estimate of overall exposure was provided by end-of-shift concentrations of 2,5-hexanedione, 3mg/g creatinine of which would correspond to ab. 50ppm of n-hexane in air (mean daily exposure).
Descriptors (primary) hexane; organic solvents; shoe industry; exposure tests; urinary metabolites
Descriptors (secondary) metabolic process; determination in urine; alveolar clearance; 2,5-hexanedione
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Biological monitoring
Aliphatic and alicyclic hydrocarbons
Footwear, leather and fur industry